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《医学前沿（英文）》 2017年 第11卷 第3期 页码 432-439 doi: 10.1007/s11684-017-0511-1
Traditional Chinese patent medicines are widely used to treat stroke because it has good efficacy in the clinical environment. However, because of the lack of knowledge on traditional Chinese patent medicines, many Western physicians, who are accountable for the majority of clinical prescriptions for such medicine, are confused with the use of traditional Chinese patent medicines. Therefore, the aid-decision method is critical and necessary to help Western physicians rationally use traditional Chinese patent medicines. In this paper, Manifold Ranking is employed to develop the aid-decision model of traditional Chinese patent medicines for stroke treatment. First, 115 stroke patients from three hospitals are recruited in the cross-sectional survey. Simultaneously, traditional Chinese physicians determine the traditional Chinese patent medicines appropriate for each patient. Second, particular indicators are explored to characterize the population feature of traditional Chinese patent medicines for stroke treatment. Moreover, these particular indicators can be easily obtained by Western physicians and are feasible for widespread clinical application in the future. Third, the aid-decision model of traditional Chinese patent medicines for stroke treatment is constructed based on Manifold Ranking. Experimental results reveal that traditional Chinese patent medicines can be differentiated. Moreover, the proposed model can obtain high accuracy of aid decision.
关键词： traditional Chinese patent medicines stroke aid decision data mining manifold ranking
Combination of western medicine and Chinese traditional patent medicine in treating a family case of
Li Ni, Ling Zhou, Min Zhou, Jianping Zhao, Dao Wen Wang
《医学前沿（英文）》 2020年 第14卷 第2期 页码 210-214 doi: 10.1007/s11684-020-0757-x
关键词： novel coronavirus (2019-nCoV) COVID-19 Chinese traditional patent medicine Shuanghuanglian oral liquid
欧盟监管环境视角下的传统医药全球化 Perspective
Werner Knoess, Jacqueline Wiesner
《工程（英文）》 2019年 第5卷 第1期 页码 22-31 doi: 10.1016/j.eng.2018.11.012
欧盟（EU）成员国对于医药产品已经进行了统一立法，其中明确定义了草药产品和传统草药产品。目的是建立一个考虑到草药产品特殊性的监管环境。统一标准旨在协调评估并促进不同成员国进入市场。欧盟草药产品委员会（HMPC）的欧盟草药专论定义的标准和《欧洲药典》规定的质量要求代表了草药和传统药物监管环境多国协调的优秀模式。此外，该框架至少部分适用于包含于中药（TCM）中的中草药和传统药物，以便进入欧盟市场。此外，HMPC还就中草药安全性和有效性的专论提供了具体的指导文件和试点项目。在《欧洲药典》中，与中药相关的草药质量的专论数量不断增加。这些发展表明与中药相关的全球化是一个持续的过程。相关监管机构、科学界和感兴趣的利益相关者之间的沟通与合作将为各种监管环境的融合奠定基础。这将有助于在适当标准的基础上在世界范围内运用传统药物。
Innovative development path of ethnomedicines: an overview of ethnomedicines in China
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《医学前沿（英文）》 2016年 第10卷 第2期 页码 166-177 doi: 10.1007/s11684-016-0448-9
In the long history of disease prevention and treatment, ancestral populations worldwide have gained knowledge and experiences in traditional medicines. For instance, ethnomedicines of Chinese ethnic minorities constitute an important part of traditional medicines. In our study, we firstly clarified the concept of ethnomedicines and the connotations of ethnopharmacology. The particularity of ethnomedicine research were then summed up, and the development profiles of the ethnomedicines of Chinese ethnic minorities were discussed by investigating the current status and existing problems. On this basis, we abstracted the innovative development path of ethnomedicines for the first time, which was found to follows:resource study → standardized development research → industrialization of the achievements and efforts for internationalization. We found that platform establishment and team training are keys to achieving innovative development. Hence, this study provided a basis for ethnomedicine development.
关键词： traditional medicines ethnomedicines Chinese ethnic minorities ethnopharmacology research mode innovative development path
The role played by traditional Chinese medicine in preventing and treating COVID-19 in China
Qingwei Li, Han Wang, Xiuyang Li, Yujiao Zheng, Yu Wei, Pei Zhang, Qiyou Ding, Jiaran Lin, Shuang Tang, Yikun Zhao, Linhua Zhao, Xiaolin Tong
《医学前沿（英文）》 2020年 第14卷 第5期 页码 681-688 doi: 10.1007/s11684-020-0801-x
关键词： traditional Chinese medicine COVID-19 Wuchang pattern mobile cabin hospital convalescent patients three formulae and three medicines
肠道微生态——探索中药临床疗效的新思路 Review
陆艳蒙, 谢娇娇, 彭聪高, 王保红, 王恺岑, 李兰娟
《工程（英文）》 2019年 第5卷 第1期 页码 40-49 doi: 10.1016/j.eng.2018.11.013
自古以来，中药在疾病预防、症状缓解和健康改善等方面发挥了重要作用。然而，复杂的成分和尚未明确的机制阻碍了中药的广泛推广和应用。越来越多的研究表明，和人体健康息息相关的肠道微生态与中药的疗效有关，因此从肠道微生态的角度去探索中药可能是打开中药奥秘的金钥匙。肠道菌群主要通过以下4个生理途径中发挥作用：参与宿主代谢、调节系统免疫、维持胃肠道稳态以及影响脑功能和宿主行为。本文回顾了中药与慢性肝病、溃疡性结肠炎、肥胖和2型糖尿病等疾病之间的联系，从肠道微生态的角度阐明其潜在的机制。未来，我们需要进一步的研究和更完善的实验设计，以揭示中药与肠道菌群之间相互作用的具体机制，并为中药的创新研究提供新的思路。
Jian Wang, Wen Zou
《医学前沿（英文）》 2011年 第5卷 第2期 页码 123-126 doi: 10.1007/s11684-011-0124-z
Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19
《医学前沿（英文）》 doi: 10.1007/s11684-023-1040-8
关键词： traditional Chinese medicine COVID-19 SARS-CoV-2 clinical evidence-based study mechanism integrated traditional Chinese and Western medicine
Barriers and countermeasures in developing traditional Chinese medicine in Europe
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《医学前沿（英文）》 2016年 第10卷 第3期 页码 360-376 doi: 10.1007/s11684-016-0455-x
Traditional Chinese medicine (TCM) is one of the unique cultural treasures of Chinese; it represents a significant feature and prominent advantage of the healthcare cause in China. Data in this paper were from World Health Organization, Chinese Bureau of Statistics, China National Knowledge Infrastructure, and PubMed. In recent years, TCM has established a solid foundation in Europe, which made great strides in legislation, education, research, and international exchange, and has enjoyed a vast development space in the continent. Now, TCM is embracing unprecedented development opportunities in Europe. At the same time, the stiff international competition poses a grave threat to China’s TCM industry. With multiple cultural, legal, and institutional challenges, as well as talent shortages in the way, TCM is now facing many difficulties in Europe. To fully prepare and enact active and vigorous steps to seize opportunities, we should have a clear picture about the serious challenges hampering TCM development in Europe. The TCM development at overseas markets has shifted from a spontaneous trade activity into a national strategy spearheaded by the government and participated in by multiple stakeholders. We should make a systematic, comprehensive, and sustainable push in fields such as TCM therapy, healthcare, education, research, culture, and industry development. The ultimate goal is to bring TCMs to the global market and allow them to play a role in safeguarding public health along with modern medicines.
Jingqing Hu, Jie Qiao, Deying Kang, Baoyan Liu
《医学前沿（英文）》 2011年 第5卷 第2期 页码 203-207 doi: 10.1007/s11684-011-0138-6
Applications of dynamical complexity theory in traditional Chinese medicine
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 279-284 doi: 10.1007/s11684-014-0367-6
Traditional Chinese medicine (TCM) has been gradually accepted by the world. Despite its widespread use in clinical settings, a major challenge in TCM is to study it scientifically. This difficulty arises from the fact that TCM views human body as a complex dynamical system, and focuses on the balance of the human body, both internally and with its external environment. As a result, conventional tools that are based on reductionist approach are not adequate. Methods that can quantify the dynamics of complex integrative systems may bring new insights and utilities about the clinical practice and evaluation of efficacy of TCM. The dynamical complexity theory recently proposed and its computational algorithm, Multiscale Entropy (MSE) analysis, are consistent with TCM concepts. This new system level analysis has been successfully applied to many health and disease related topics in medicine. We believe that there could be many promising applications of this dynamical complexity concept in TCM. In this article, we propose some promising applications and research areas that TCM practitioners and researchers can pursue.
关键词： traditional Chinese medicine Multiscale Entropy dynamical complexity system level applications
Understanding channel tropism in traditional Chinese medicine in the context of systems biology
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《医学前沿（英文）》 2013年 第7卷 第3期 页码 277-279 doi: 10.1007/s11684-013-0273-3
Channel tropism is investigated and developed through long-term clinical practice. In recent years, the development of channel tropism theory has attracted increasing attention. This study analyzed channel tropism theory and the problems associated with it. Results showed that this theory and systems biology have a similar holistic viewpoint. Systems biology could provide novel insights and platform in the study of channel tropism. Some problems in channel tropism theory, including pharmacology and action mechanism, were investigated.
关键词： systems biology channel tropism theory traditional Chinese medicine application
Ontological reconstruction of the clinical terminology of traditional Chinese medicine
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 358-361 doi: 10.1007/s11684-014-0348-9
This study proposes the ontological reconstruction of the current clinical terminology of traditional Chinese medicine (TCM). It also provides an overview of preliminary work related to the said reconstruction, including the ontology-based analysis of TCM clinical terminology. We conclude that the ontological reconstruction of TCM clinical terminology provides a proper translation from the idealized organizational model to real-world implementation and to a formalized, shared, and knowledge-based framework.
关键词： ontology traditional Chinese medicine clinical terminology
Clinical research of traditional Chinese medicine in big data era
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《医学前沿（英文）》 2014年 第8卷 第3期 页码 321-327 doi: 10.1007/s11684-014-0370-y
With the advent of big data era, our thinking, technology and methodology are being transformed. Data-intensive scientific discovery based on big data, named “The Fourth Paradigm,” has become a new paradigm of scientific research. Along with the development and application of the Internet information technology in the field of healthcare, individual health records, clinical data of diagnosis and treatment, and genomic data have been accumulated dramatically, which generates big data in medical field for clinical research and assessment. With the support of big data, the defects and weakness may be overcome in the methodology of the conventional clinical evaluation based on sampling. Our research target shifts from the “causality inference” to “correlativity analysis.” This not only facilitates the evaluation of individualized treatment, disease prediction, prevention and prognosis, but also is suitable for the practice of preventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinese medicine (TCM), and for the post-marketing evaluation of Chinese patent medicines. To conduct clinical studies involved in big data in TCM domain, top level design is needed and should be performed orderly. The fundamental construction and innovation studies should be strengthened in the sections of data platform creation, data analysis technology and big-data professionals fostering and training.
关键词： big data traditional Chinese medicine clinical evaluation evidence based medicine
Developments in cancer prevention and treatment using traditional Chinese medicine
Hongsheng Lin, Jie Liu, Ying Zhang
《医学前沿（英文）》 2011年 第5卷 第2期 页码 127-133 doi: 10.1007/s11684-011-0137-7
标题 作者 时间 类型 操作
A novel classification method for aid decision of traditional Chinese patent medicines for stroke treatment
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期刊论文
Combination of western medicine and Chinese traditional patent medicine in treating a family case of
Li Ni, Ling Zhou, Min Zhou, Jianping Zhao, Dao Wen Wang
期刊论文
The role played by traditional Chinese medicine in preventing and treating COVID-19 in China
Qingwei Li, Han Wang, Xiuyang Li, Yujiao Zheng, Yu Wei, Pei Zhang, Qiyou Ding, Jiaran Lin, Shuang Tang, Yikun Zhao, Linhua Zhao, Xiaolin Tong
期刊论文
Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China
Jian Wang, Wen Zou
期刊论文
Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19
期刊论文
Analysis on the distinguishing features of traditional Chinese therapeutics and related statistical issues
Jingqing Hu, Jie Qiao, Deying Kang, Baoyan Liu
期刊论文
Understanding channel tropism in traditional Chinese medicine in the context of systems biology
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期刊论文
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